Perio Bacteria Spur Cancer Growth in Mouth

Case Western Reserve University has found two bacteria prevalent in periodontal disease from small fatty acids that incite growth of deadly Kaposi’s sarcoma (KS) related lesions and tumors in the mouth. Their discovery could be key to the development of testing and preventive treatments. Saliva testing for the bacteria can lead to early treatment and monitoring for signs of KS before malignancy develops. The two bacteria associated with periodontal disease are known as Porphyromonas gingivalis and Fusobacterium nucleatum. They are suspected to contribute to the replication of Kaposi’s sarcoma-associated herpesvirus (KSHV) and the development of KS in the mouth. Researchers did a study of a saliva sample with two different groups, one had severe chronic periodontal disease and the other had healthy gums, practiced good oral health and showed no signs of bleeding or tooth loss from periodontal disease. “The most important thing to come out of this study is that we believe periodontal disease is a risk factor for Kaposi sarcoma tumor in HIV patients,” said Fengchun Ye, PhD, the study’s lead investigator.  The study did not show that people with periodontal disease are actually at a higher risk for developing KS lesions in the mouth.

For more information:

See the article, “Short Chain Fatty Acids from Periodontal Pathogens Suppress HDACs, EZH2, and SUV39H1 to Promote Kaposi’s Sarcoma-Associated Herpesvirus Replication,” Feb. 5, 2014, Journal of Virology.

Perio Bacteria Pic 8-12-14

The 39th Annual Meeting of the American Academy of Esthetic Dentistry

Bacara Resort 8-5-14

Dr. Sheets, Dr. Paquette and Dr. Wu are attending the 39th Annual Meeting of American Academy of Esthetic Dentistry August 5- August 8, 2014. The Meeting is being held at the gorgeous Bacara Resort & Spa in Santa Barbara. The theme of the meeting is “The Legacy of Esthetic Dentistry,” which will seek to show how Doctors are bringing that tradition into the future. The Doctors will be lecturing on Evolving Concepts of Patient Care” and highlighting six patients within our Practice. With the progressive introduction of new technologies and dental biomaterials, the Doctors continue to redefine the approach to treatment of the esthetic rehabilitative patient. Yet, with each progression of advancements, one must reflect on the potential for contribution to greater successful outcomes vs. following current trends.  Past treatments once viewed as “state of the art” can sometimes be viewed as “dinosaurs of the past” due to today’s options.  The Doctor’s quest to recreate nature has been fulfilled for many patients, however, within their lecture the objective will be to critically examine the current evolution of treatment options.

At the conclusion of this lecture participants will have a better understanding of:

  1. How new technologies such as CAD/CAM and dental materials can be incorporated into older treatment plans to optimize results.
  2. How to sequence treatment plans to enhance longevity of complex interdisciplinary cases.
  3. When to be conservative and when to be bold in approaching comprehensive treatment to maximize long term results.

Stem Cells From Teeth Can Make Brain-like Cells

Laboratory studies at the University Centre for Stem Cell Research have found stem cells from teeth can develop and form complex networks of brain-like cells. University of Adelaide researchers have discovered that stem cells taken from teeth can grow to resemble brain cells, suggesting these cells can be used in the brain as a therapy for strokes.  “Stem cells from teeth have great potential to grow into new brain or nerve cells, and this could potentially assist with treatments of brain disorders such as stroke, “ said Kylie Ellis, PhD. Dr. Ellis is the commercial development manager with the university’s commercial arm, Adelaide Research & Innovation. The goal is to be able to utilize a patient’s own stem cells for tailor-made brain therapy with less rejection issues commonly found with cell-based therapies. Although these cells have not developed into full-fledged neurons, researchers believe it is only a matter of time and the right conditions for that to happen.

For more information:

See the article, “Neurogenic Potential of Dental Pulp Stem Cells Isolated From Murine Incisors” published in Stem Cell Research & Therapy, February 27, 2014, vol. 5:30.

Stem Cells From Teeth 7-29-14

May is National High Blood Pressure Education Month

May is National High Blood Pressure Education Month

Heart disease and stroke are the first and fourth leading causes of death in the United States. Heart disease is responsible for 1 of every 4 deaths in the country. Educating patients about high blood pressure and the need for control is essential to long-term health. In fact, high blood pressure is one of the most important risk factors for heart disease, stroke, kidney disease, and diabetes complications. The American Dental Association has partnered with dozens of organizations to support the Million Hearts initiative which launched in 2012. The Million Hearts® will focus, coordinate, and enhance cardiovascular disease prevention activities across the public and private sectors in an unprecedented effort to prevent 1 million heart attacks and strokes by 2017 and demonstrate to the American people that improving the health system can save lives. Million Hearts® will scale-up proven clinical and community strategies to prevent heart disease and stroke across the nation.

The Centers for Disease Control and Prevention encourages patients to check blood pressure- it is easy and it painless. It can be checked by your doctor, and many pharmacies have free screenings. According to the CDC, if you currently have high blood pressure, below are easy steps to manage and lower your blood pressure:
1. Ask your doctor what your blood pressure should be. Set a goal to lower your pressure with your doctor and then discuss how you can reach your goal. Work with your health care team to make sure you meet that goal.
2. Take your blood pressure medication as directed.
3. Quit smoking
4. Reduce sodium.

National Prosthodontics Awareness Week- April 7, 2014

National Prosthodontics Awareness Week- April 7, 2014

A primary focus of Prosthodontics is the replacement of missing teeth to restore optimal function, appearance, and oral health. Prosthodontists are dental specialists in the restoration and replacement of teeth who have completed dental school plus three additional years of advanced specialty training and education. Prosthodontists provide an extremely high level of care to patients with missing teeth, or having significant damage to their existing teeth. They also work with congenital defects as well as problems arising from trauma and neglect. . Prosthodontists are highly trained in state-of-the-art techniques and procedures for treating many diverse and complex dental conditions and restoring optimum function and esthetics. These include: crowns, bridges, complete and removable partial dentures, dental implants, TMD-jaw joint problems, traumatic injuries to the mouth’s structure and/or teeth, snoring or sleep disorders and oral cancer reconstruction and continuing care. Prosthodontists are proficient in comprehensive oral health diagnosis, treatment planning and restoration. A Prosthodontist is the skilled architect who can restore optimal function and appearance to your smile. (Information provided by: Fort Gordon Dental Activity)

World Oral Health Day March 20, 2014

 Today, 50 countries worldwide are “Celebrating Healthy Smiles” on World Oral Health Day!  The 2014 day is organized by the FDI World Dental Federation with the collaboration of the ADA. FDI World Dental Federation serves as the principal representative body for more than one million dentists worldwide, developing health policy and continuing education programmes, speaking as a unified voice for dentistry in international advocacy, and supporting member associations in global oral health promotion activities. The annual observance offers FDI member dental associations, schools, companies and other groups the opportunity to reach local communities. According to the FDI, 90% of the world’s population will suffer from oral diseases in their lifetime. WOHD 2014 focuses on reminding the young and the old of the importance of protecting the teeth and mouth throughout life. Visit for the latest news and a variety of downloadable materials!